Synthesis, anti-human immunodeficiency virus and anti-hepatitis B virus activities of novel oxaselenolane nucleosides

J Du, S Surzhykov, JS Lin, MG Newton…

文献索引：Du, Jinfa; Surzhykov, Sergey; Lin, Ju Sheng; Newton, M. Gary; Cheng, Yung-Chi; Schinazi, Raymond F.; Chu, Chung K. Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 2991 - 2993

全文：HTML全文

被引用次数: 26

摘要

Since dioxolane1-4 and oxathiolane5-10 nucleosides have exhibited promising antiviral and anticancer activities, it was of interest to synthesize an isosteric class of compounds, oxaselenolane nucleosides in search of biologically interesting nucleosides. Despite their structural similarity to the known 3′-heteroatomsubstituted nucleosides, the synthesis of oxaselenolane nucleosides has been elusive. A plausible method for the construction of ...