Synthesis, anti-human immunodeficiency virus and anti-hepatitis B virus activities of novel oxaselenolane nucleosides

J Du, S Surzhykov, JS Lin, MG Newton…

Index: Du, Jinfa; Surzhykov, Sergey; Lin, Ju Sheng; Newton, M. Gary; Cheng, Yung-Chi; Schinazi, Raymond F.; Chu, Chung K. Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 2991 - 2993

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Citation Number: 26

Abstract

Since dioxolane1-4 and oxathiolane5-10 nucleosides have exhibited promising antiviral and anticancer activities, it was of interest to synthesize an isosteric class of compounds, oxaselenolane nucleosides in search of biologically interesting nucleosides. Despite their structural similarity to the known 3′-heteroatomsubstituted nucleosides, the synthesis of oxaselenolane nucleosides has been elusive. A plausible method for the construction of ...