Cyclopropyl and Cyclobutyl Analogs of Phenyl-Substituted Medicinal Agents1a, b

A Burger, RT Standridge, EJ Ariens

文献索引：Burger,A. et al. J. Med. Chem., 1963 , vol. 6, p. 221 - 227

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被引用次数: 7

摘要

Cyclobutgl analogs of the following phenyl-substituted drugs have been synthesized: phenobarbital, a-phenyl-~-niethylsaccinimide, phenylbutazone, cinchophen and 4-amino-2- phenylquinoline. The cgclobutj-1 group can replace effectively a 1-cyclohesenyl group in hypnotic barbiturates, but produces no synipathominietic effects in the cyclobutgl analog of amphetamine, nor does it lead to significant metabolite antagonism in 8-cgclobutyl-a- ...