Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest

RS Dothager, KS Putt, BJ Allen, BJ Leslie…

文献索引：Dothager, Robin S.; Putt, Karson S.; Allen, Brittany J.; Leslie, Benjamin J.; Nesterenko, Vitaliy; Hergenrother, Paul J. Journal of the American Chemical Society, 2005 , vol. 127, # 24 p. 8686 - 8696

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被引用次数: 67

摘要

Late-stage malignant melanoma is a cancer that is refractory to current chemotherapeutic treatments. The average survival time for patients with such a diagnosis is 6 months. In general, the vast majority of anticancer drugs operate through induction of cell cycle arrest and cell death in either the DNA synthesis (S) or mitosis (M) phase of the cell cycle. Unfortunately, the same mechanisms that melanocytes possess to protect cells from DNA ...