Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest

RS Dothager, KS Putt, BJ Allen, BJ Leslie…

Index: Dothager, Robin S.; Putt, Karson S.; Allen, Brittany J.; Leslie, Benjamin J.; Nesterenko, Vitaliy; Hergenrother, Paul J. Journal of the American Chemical Society, 2005 , vol. 127, # 24 p. 8686 - 8696

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Citation Number: 67

Abstract

Late-stage malignant melanoma is a cancer that is refractory to current chemotherapeutic treatments. The average survival time for patients with such a diagnosis is 6 months. In general, the vast majority of anticancer drugs operate through induction of cell cycle arrest and cell death in either the DNA synthesis (S) or mitosis (M) phase of the cell cycle. Unfortunately, the same mechanisms that melanocytes possess to protect cells from DNA ...