The Journal of Organic Chemistry

Studies on the reactivity of bicyclomycin with nucleophilic amino acid derivatives

S Abuzar, H Kohn

文献索引：Abuzar, Syed; Kohn, Harold Journal of Organic Chemistry, 1989 , vol. 54, # 16 p. 4000 - 4003

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被引用次数: 16

摘要

Bicyclomycin (1) is a clinically useful antibiotic marketed under the trade name Bicozamycin. Its unique structure and broad spectrum of antimicrobial activity have contributed to the increasing interest in this drug." 15 Biochemical studies indicate that 1 binds with select bacterial inner-membrane proteins (ie, sulfhydryl-containing residues) leading to the disruption of cell wall gr~ wth.~ Controversy exists as to whether drug activation occurs by ...