Amides of n-acylcysteines as mucolytic agents

TA Martin, DH Causey, AL Sheffner…

文献索引：Martin,T.A. et al. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 1172 - 1176

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被引用次数: 9

摘要

Mucolytic Data.-The activity of three compounds in reducing the viscosity of a mucoproteinlz solution is shown in Table 11. XAC is included as reference material. Substantially greater mucolytic activity is demon5tr:~ ted by the 2-acylamino-3-mercaptopropiorl-amides (1-5) ut each time period. Two less soluble compounds (6 and 7) do not show good activity. Oxidative Stability.-In addition to the good mucolytic I) ropertics esliihitccl by severd of ...