A Catalytic Asymmetric Reaction Involving Enolizable Anhydrides

C Cornaggia, F Manoni, E Torrente, S Tallon…

文献索引：Cornaggia, Claudio; Manoni, Francesco; Torrente, Esther; Tallon, Sean; Connon, Stephen J. Organic Letters, 2012 , vol. 14, # 7 p. 1850 - 1853

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被引用次数: 23

摘要

In the presence of a highly efficient novel bifunctional organocatalyst at low loadings under mild conditions, enolizable homophthalic anhydrides can be added to a range of aromatic and aliphatic aldehydes to give dihydroisocoumarins, with excellent yields and diastereo- and enantiocontrol (up to 99% ee).