Synthesis and biological evaluation of 2, 3-diaryl isoquinolinone derivatives as anti-breast cancer agents targeting ERα and VEGFR-2

Z Tang, S Niu, F Liu, K Lao, J Miao, J Ji, X Wang…

文献索引：Tang, Zhichao; Niu, Shaoxiong; Liu, Fei; Lao, Kejing; Miao, Jingshan; Ji, Jinzi; Wang, Xiang; Yan, Ming; Zhang, Luyong; You, Qidong; Xiao, Hong; Xiang, Hua Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 9 p. 2129 - 2133

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被引用次数: 7

摘要

Abstract The estrogen receptor α is recognized as important pharmaceutical target for breast cancer therapy, and vascular endothelial growth factor receptors (VEGFRs) play important roles in tumor angiogenesis including breast cancer. A series of 2, 3-diaryl isoquinolinone derivatives were designed and synthesized targeting both estrogen receptor α (ERα) and VEGFR-2. Bioactivity evaluation showed that compounds 7c, 7d and 7f exhibited ...