Synthesis and receptor affinities of new 3??quinuclidinyl α??heteroaryl?螃窿?aryl?螃窿?hydroxyacetates

…, R de la Cruz, MS Gitler, E Hariman…

文献索引：Cohen; Gibson; Fan; De la Cruz; Gitler; Hariman; Reba Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 4 p. 326 - 329

全文：HTML全文

被引用次数: 15

摘要

Abstract Five analogues of 3-quinuclidinyl benzilate were prepared in which one phenyl ring was substituted by a heterocycle; a bromine was included on either the remaining phenyl or the heterocycle to provide information relating to the affinity of potential radiohalogenated derivatives. Their affinities for the muscarinic cholinergic receptor were determined. Replacing a phenyl ring with either the 2-or 3-furyl moiety or the 2-or 3-thienyl moiety did ...