Palladium-catalyzed reactions of hypophosphorous compounds with allenes, dienes, and allylic electrophiles: methodology for the synthesis of allylic H-phosphinates

K Bravo-Altamirano, I Abrunhosa-Thomas…

文献索引：Bravo-Altamirano, Karla; Abrunhosa-Thomas, Isabelle; Montchamp, Jean-Luc Journal of Organic Chemistry, 2008 , vol. 73, # 6 p. 2292 - 2301

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被引用次数: 47

摘要

Hypophosphorous compounds (MOP (O) H2, M= H, R3NH) effectively participate in metal- catalyzed CP bond-forming reactions with allenes, dienes, and activated allylic electrophiles under mild conditions. The catalytic system Pd2dba3/xantphos is crucial to avoid or minimize the competitive reductive transfer-hydrogenation pathway available to hypophosphorous acid derivatives. Further investigation into the allylation mechanism ...