e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Palladium-catalyzed reactions of hypophosphorous compounds with allenes, dienes, and allylic electrophiles: methodology for the synthesis of allylic H-phosphinates
Hypophosphorous compounds (MOP (O) H2, M= H, R3NH) effectively participate in metal- catalyzed CP bond-forming reactions with allenes, dienes, and activated allylic electrophiles under mild conditions. The catalytic system Pd2dba3/xantphos is crucial to avoid or minimize the competitive reductive transfer-hydrogenation pathway available to hypophosphorous acid derivatives. Further investigation into the allylation mechanism ...
