Tetrahedron Letters

Inverse electron-demand Diels–Alder chemistry in the synthesis of a regioselectively protected analogue of the staurosporine aglycone

R Nomak, JK Snyder

文献索引：Nomak, Rana; Snyder, John K. Tetrahedron Letters, 2001 , vol. 42, # 45 p. 7929 - 7933

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被引用次数: 32

摘要

Regioselective Weinreb amidation of the C1 ester of dimethyl pyridazino [4, 5-b] indole-1, 4- dicarboxylate followed by an intramolecular inverse electron-demand Diels–Alder reaction and palladium-catalyzed coupling produced regioselectively protected N6-methylindolo [2, 3- a] pyrrolo [3, 4-c] carbazole (N6-methylstaurosporinone).