Tetrahedron

Highly selective TFAA-cleavage of tertiary 2, 4-dimethoxybenzylamines and its use in the synthesis of secondary amines

P Nussbaumer, K Baumann, T Dechat, M Harasek

文献索引：Nussbaumer; Baumann; Dechat; Harasek Tetrahedron, 1991 , vol. 47, # 26 p. 4591 - 4602

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被引用次数: 15

摘要

TFAA-treatment of allylic, propargylic, homopropargylic and some benzylic tert. 2, 4- dimethoxybenzylamines leads to highly selective cleavage of their dimethoxybenzylic C N bonds. The resultant trifluoroacetamides can then readily be converted to the corresponding secondary amines.