A Bridged Porphyrinato (thiolato) iron (III) Complex as a Model of the Active Center of the Cytochrome P??450 Isozyme

H Volz, M Holzbecher

文献索引：Volz; Holzbecher Angewandte Chemie - International Edition in English, 1997 , vol. 36, # 13-14 p. 1442 - 1445

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被引用次数: 36

摘要

The ubiquitous cytochrome P-450 isozymes are heme-thiolate enzymes, which function as oxygen-activating components in monooxygenase systems. They play a vital role both in the construction and destruction of cellular substances, catalyze the oxidative metabolism of lipophilic xenobiotics,"] activate vitamins, and convert a range of chemical compounds into carcinogens in the course of chemical cancerogenesis.['I Under anaerobic conditions 0 ...