Synthesis, anti-mycobacterial, anti-trichomonas and anti-candida in vitro activities of 2-substituted-6, 7-difluoro-3-methylquinoxaline 1, 4-dioxides

…, G Paglietti, A Mattana, PL Fiori, P Mollicotti…

文献索引：Carta, Antonio; Loriga, Mario; Paglietti, Giuseppe; Mattana, Antonella; Fiori, Pier Luigi; Mollicotti, Paola; Sechi, Leonardo; Zanetti, Stefania European Journal of Medicinal Chemistry, 2004 , vol. 39, # 2 p. 195 - 203

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被引用次数: 78

摘要

A new series of 23 6, 7-difluoro-3-methyl-2-phenylthio/phenylsulfonyl/phenylsulfinyl/ benzylamino/phenylamino-quinoxaline 1, 4-dioxides variously substituted in the phenyl moiety, was synthesized and submitted to in vitro evaluation for anti-mycobacterial, anti- trichomonas, anti-candida, anti-mycoplasma and antibacterial activities. In anti- mycobacterial assays, several compounds resulted active (MIC90= 2.0–4.0 μg/ml) against ...