Synthesis of second-generation Sansalvamide A derivatives: Novel templates as potential antitumor agents

…, JD Brown, J Cajica, E Parry, K Otrubova…

文献索引：Rodriguez, Rodrigo A.; Pan, Po-Shen; Pan, Chung-Mao; Ravula, Suchitra; Lapera, Stephanie; Singh, Erinprit K.; Styers, Thomas J.; Brown, Joseph D.; Cajica, Julia; Parry, Emily; Otrubova, Katerina; McAlpine, Shelli R. Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 1980 - 2002

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被引用次数: 45

摘要

We report the synthesis of 34 second-generation Sansalvamide A derivatives. San A derivatives have unique anticancer properties and target multiple cancers, including colon, pancreatic, breast, prostate, and melanoma. As novel templates, the derivatives described herein explore the role of stereochemistry, amide bond geometry, transannular hydrogen bonding, and polarity on antitumor potency. Testing the chemotherapeutic activity of these ...