Antibody recognition of chiral surfaces. Enantiomorphous crystals of leucine-leucine-tyrosine

…, F Frolow, M Eisenstein, L Addadi

文献索引：Geva, Merav; Frolow, Felix; Eisenstein, Miriam; Addadi, Lia Journal of the American Chemical Society, 2003 , vol. 125, # 3 p. 696 - 704

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被引用次数: 36

摘要

Monoclonal antibodies were selected after immunization with crystals of the tripeptide l- leucine-l-leucine-l-tyrosine. They interact with the tripeptide crystals, but do not interact with the tripeptide molecule, with other crystalline surfaces, or with adsorbed protein. The interactions of two antibodies with crystals of l-Leu-l-Leu-l-Tyr and of its enantiomer d-Leu-d- Leu-d-Tyr were characterized in depth. Antibody 48E is stereoselective and ...