Journal of Heterocyclic Chemistry

New efficient and flexible synthetic route to emivirine and its analogs

L Li, L Ma, X Wang, J Liu

文献索引：Li, Li; Ma, Liying; Wang, Xiaowei; Liu, Junyi Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 164 - 168

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被引用次数: 4

摘要

Abstract A revised synthetic route to Emivirine (MKC-442) via properly substituted β-keto ester converted from Meldrum's Acid was developed. This method could be applied to the synthesis of a variety of MKC-442 analogues and open the way for their systematic biological evaluation.