The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase

…, M Buděšínský, J Mládková, TA Garrow…

文献索引：Picha, Jan; Vanek, Vaclav; Budesinsky, Milos; Mladkova, Jana; Garrow, Timothy A.; Jiracek, Jiri European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 256 - 275

全文：HTML全文

被引用次数: 7

摘要

Abstract Betaine-homocysteine S-methyltransferase (BHMT) is an important zinc-dependent methyltransferase that uses betaine as the methyl donor for the remethylation of homocysteine to form methionine. In the liver, BHMT performs to half of the homocysteine remethylation. In this study, we systematically investigated the tolerance of the enzyme for modifications at the “homocysteine” part of the previously reported potent inhibitor (R, S)-5 ...