Synthesis of β-hydroxyphosphonate and 1, 2-dihydroxy acyclic nucleoside analogs via 1, 3-dipolar cycloaddition strategy

M Ganesan, KM Muraleedharan

文献索引：Ganesan; Muraleedharan Nucleosides, Nucleotides and Nucleic Acids, 2010 , vol. 29, # 2 p. 91 - 96

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被引用次数: 13

摘要

Synthesis of nucleoside analogs with biomimetically modified “sugar” or the “base” moieties is an area of tremendous interest due to their potential to target pathogens such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and cytomegalovirus (CMV). [ 1 1. De Clercq , E. and Holy , A. 2005. Case history: Acyclic nucleoside phosphonates: A key class of antiviral drugs. Nat. Rev. Drug Discovery, 4: 928–940. [CrossRef], [PubMed], [Web of ...