A method for the synthesis of racemic and optically active 2??substituted 9??(2′, 3′??dihydroxypropyl)??8??azahypoxanthines and 8??azaadenines

…, G Biagi, I Giorgi, O Livi, V Scartoni

文献索引：Barili; Biagi; Giorgi; Livi; Scartoni Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 5 p. 1351 - 1355

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被引用次数: 12

摘要

Abstract Several 9-(2′, 3′-O-isopropylidene)-and 9-(2′, 3′-dihydroxypropyl)-8- azahypoxanthines and 8-azaadenines were synthesized by a “one pot” method starting from the acetonide of racemic or (S)-1-azido-2, 3-dihydroxypropane, obtained from D-mannitol. 9- (2′, 3′-Dihydroxypropyl)-8-azapurines were tested as adenosine deaminase inhibitors.