Peripheral substituents of di (pyridiumyl) porphyrins affected on their interactions with DNA

…, P Wang, T Tian, L Wu, H He, X Zhou, X Zhang…

文献索引：Wu, Song; Wang, Ping; Tian, Tian; Wu, Lin; He, Hanping; Zhou, Xiang; Zhang, Xiaolian; Cao, Xiaoping Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2575 - 2577

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被引用次数: 6

摘要

meso-and β-Substituted di (pyridiumyl) porphyrins 3, 4, and 7 have been synthesized and their interactions with DNA have been investigated. meso-Substituted porphyrins showed the stronger effect on DNA than that of β-substituted porphyrin. Cytoxicity of compound 3 (IC50) to THP-1 tumor cell was up to 0.11 nM.