Synthesis of the NK1 Receptor Antagonist GW597599. Part 1: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine

G Guercio, S Bacchi, M Goodyear…

文献索引：Organic Process Research and Development, , vol. 12, # 6 p. 1188 - 1194

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被引用次数: 21

摘要

... The result was a simplified workup procedure and a consistent lower level of the impurity 24 ... Unfortunately, this process required purification on silica gel because it was easily undermined by the ... This meant that the water contamination of the organic layer containing the raceme ...