Synthesis of the NK1 Receptor Antagonist GW597599. Part 3: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine Urea, A Happy End

G Guercio, S Bacchi, A Perboni, C Leroi…

文献索引：Organic Process Research and Development, , vol. 13, # 6 p. 1100 - 1110

全文：HTML全文

被引用次数: 11

摘要

... Organic Process Research & Development. ... by chromatography to isolate a single diastereoisomer of 1 which underwent a further classical resolution procedure to obtain ... The starting conditions of the process were: triphosgene (0.45 equiv) was dissolved in ethyl acetate (12 vol ...