Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo

MAL Blackie, V Yardley, K Chibale

文献索引：Blackie, Margaret A.L.; Yardley, Vanessa; Chibale, Kelly Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 1078 - 1080

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被引用次数: 20

摘要

Synthesis of the potent antiplasmodial 4-aminoquinoline, phenylequine (PQ), is reported for the first time. PQ and the two analogues show increased efficacy in moving from the chloroquine sensitive D10 to the chloroquine resistant K1 strain in vitro. The in vivo efficacy of PQ, and salts thereof, have been determined in Plasmodium berghei ANKA and Plasmodium yoelii. Phenylequine hydrochloride has shown an ED50 of 0.81 in P. yoelii (cf ...