Synlett

Facile Synthesis of Fluorinated Pyrrolo [2, 3-b] pyridines

U Groth, VO Iaroshenko, Y Wang, T Wesch

文献索引：Groth, Ulrich; Iaroshenko, Viktor O.; Wang, Yan; Wesch, Thomas Synlett, 2009 , # 3 p. 456 - 460

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被引用次数: 1

摘要

Abstract With the purpose to synthesize novel ADAs (adenosine deaminase) and IMPDH (inosine 5′-monophosphate dehydrogenase) inhibitors the reaction of 5-amino-1-tert-butyl- 1H-pyrrolo-3-carbonitrile with fluorinated 1, 3-biselectrophiles was studied. An efficient and convenient synthetical approach to obtain fluorinated pyrrolo [2, 3-b] pyridines was developed. tert-Butyl protecting group was successfully cleaved by treating of synthesized ...