Synthesis and pharmacological evaluation of new 1, 2-dithiolane based antioxidants

…, MV Fouquier-d'Hérouël, M Bertrand, B Lockhart…

文献索引：Guillonneau, Claude; Charton, Yves; Ginot, Yves-Michel; Fouquier-D'Herouel, Marie-Victoire; Bertrand, Marc; Lockhart, Brian; Lestage, Pierre; Goldstein, Solo European Journal of Medicinal Chemistry, 2003 , vol. 38, # 1 p. 1 - 11

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被引用次数: 21

摘要

Molecules containing a dithiolane moiety are widely investigated due to their antioxidant properties. The archetypal representative of this class of compounds is lipoic acid and indeed the lipoic acid–dihydrolipoic acid couple is part of the antioxidant defence system of the cell. In the course of a program aiming to find improved antioxidants effective in vivo, we designed, synthesised and pharmacologically investigated new lipoic acid analogs. The ...