Synthesis and pharmacological evaluation of new 1, 2-dithiolane based antioxidants

…, MV Fouquier-d'Hérouël, M Bertrand, B Lockhart…

Index: Guillonneau, Claude; Charton, Yves; Ginot, Yves-Michel; Fouquier-D'Herouel, Marie-Victoire; Bertrand, Marc; Lockhart, Brian; Lestage, Pierre; Goldstein, Solo European Journal of Medicinal Chemistry, 2003 , vol. 38, # 1 p. 1 - 11

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Citation Number: 21

Abstract

Molecules containing a dithiolane moiety are widely investigated due to their antioxidant properties. The archetypal representative of this class of compounds is lipoic acid and indeed the lipoic acid–dihydrolipoic acid couple is part of the antioxidant defence system of the cell. In the course of a program aiming to find improved antioxidants effective in vivo, we designed, synthesised and pharmacologically investigated new lipoic acid analogs. The ...