Tetrahedron: Asymmetry

Enantioselective borane reduction of prochiral ketones catalyzed by a chloro-containing chiral β-amino alcohol

ZX Shen, J Lu, Q Zhang, YW Zhang

文献索引：Shen, Zong-Xuan; Lu, Jun; Zhang, Qing; Zhang, Ya-Wen Tetrahedron Asymmetry, 1997 , vol. 8, # 14 p. 2287 - 2289

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被引用次数: 10

摘要

A chloro-containing chiral β-amino alcohol (S)-2-amino-3-(2-chlorophenyl)-1, 1-diphenyl-1- propanol (1) was prepared from the related amino acid, which was synthesized via malonic ester method. As a catalyst for the enantioselective borane reduction of prochiral ketones, 1 is better than those that have a similar structure but have no halogen atom in the molecule.