Tetrahedron letters

The synthesis of β-lactams via a one-pot Reformatsky reaction of imines promoted by Zn/Cp 2 TiCl 2 (cat.)

L Chen, G Zhao, Y Ding

文献索引：Chen, Lei; Zhao, Gang; Ding, Yu Tetrahedron Letters, 2003 , vol. 44, # 12 p. 2611 - 2614

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被引用次数: 29

摘要

In the presence of Zn/Cp2TiCl2 (cat.) α-bromoacetates, γ-bromocrotonates or α- bromomethylacrylates react with imines in one-pot to form β-lactams, 3-vinyl-β-lactams or α- methylene-γ-lactams, respectively, at room temperature without the need for pretreatment of the solvent and Zn.