β-Lactam formation by ultrasound-promoted reformatsky type reaction

AK Bose, K Gupta, MS Manhas

文献索引：Bose, Ajay K.; Gupta, Kavita; Manhas, M. S. Journal of the Chemical Society, Chemical Communications, 1984 , # 2 p. 86 - 87

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被引用次数: 18

摘要

Ultrasound was found to promote the reaction between ethyl bromoacetate, zinc, and a Schiff base such that an excellent yield of P-lactams was obtained in a few hours at room temperature. ... Most p-lactam antibiotics found in nature are characterized by an a-aniido or an a-methanol side chain. Clavulanic acid (1) and related antibiotics' constitute so far the only p-lactam family that carries no substituent on the carbon adjacent to the p-lactam ...