Steroids

Synthesis and biochemical studies of estrone sulfatase inhibitors

…, R Pillai, BL Young, WH Bender, DM Martino, FT Lin

文献索引：Li, Pui-Kai; Pillai, Radhakrishnan; Young, Barry L.; Bender, William H.; Martino, Dino M.; Lin, Fu-Tyan Steroids, 1993 , vol. 58, # 3 p. 106 - 111

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被引用次数: 47

摘要

Abstract The synthesis and biochemical evaluation of estrone sulfatase inhibitors are described. Inhibitors were designed through modifications of the substrate estrone sulfate. An in vitro assay using the microsomal fraction isolated from human term placenta was used to evaluate sulfatase inhibitory activity. All the inhibitors (except sulfonyl chloride analog) exhibited low inhibitory activities in the screening assay. Sulfonyl chloride analog is a ...