Chemical Communications

Direct N-cyclopropylation of secondary acyclic amides promoted by copper

E Racine, F Monnier, JP Vors, M Taillefer

文献索引：Racine, Emilie; Monnier, Florian; Vors, Jean-Pierre; Taillefer, Marc Chemical Communications, 2013 , vol. 49, # 67 p. 7412 - 7414

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被引用次数: 13

摘要

The N-cyclopropylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper system. The corresponding tertiary acyclic amides, which constitute a wide family of biologically active compounds, have been obtained in good to excellent yields.