Chemical Communications

Direct N-cyclopropylation of secondary acyclic amides promoted by copper

E Racine, F Monnier, JP Vors, M Taillefer

Index: Racine, Emilie; Monnier, Florian; Vors, Jean-Pierre; Taillefer, Marc Chemical Communications, 2013 , vol. 49, # 67 p. 7412 - 7414

Full Text: HTML

Citation Number: 13

Abstract

The N-cyclopropylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper system. The corresponding tertiary acyclic amides, which constitute a wide family of biologically active compounds, have been obtained in good to excellent yields.

~83%

Pd (OAc) 2-Catalyzed Carbonylative Coupling of Aryl Iodide w...

[Tambade, Pawan J.; Patil, Yogesh P.; Qureshi, Ziyauddin S.; Dhake, Kishor P.; Bhanage, Bhalchandra M. Synthetic Communications, 2012 , vol. 42, # 2 p. 176 - 185]

Copper catalyzed N-arylation between aryl halides and nitril...

[Wang, Jichao; Yin, Xinchi; Wu, Jun; Wu, Datong; Pan, Yuanjiang Tetrahedron, 2013 , vol. 69, # 48 p. 10463 - 10469]

Facile Conversion of Thioamides into the Corresponding Amide...

[Inamoto, Kiyofumi; Shiraishi, Mitsugu; Hiroya, Kou; Doi, Takayuki Synthesis, 2010 , # 18 p. 3087 - 3090]

Bis (cyclopentadienyldicarbonyliron) as a Convenient Carbon ...

[Nakaya, Ryotaro; Yorimitsu, Hideki; Oshima, Koichiro Chemistry Letters, 2011 , vol. 40, # 9 p. 904 - 906]

Use of Molecular Oxygen as a Reoxidant in the Synthesis of 2...

[Inamoto, Kiyofumi; Hasegawa, Chisa; Kawasaki, Junpei; Hiroya, Kou; Doi, Takayuki Advanced Synthesis and Catalysis, 2010 , vol. 352, # 14-15 p. 2643 - 2655]