Biosynthetic origin and mechanism of formation of the aminoribosyl moiety of peptidyl nucleoside antibiotics

…, P Pahari, K Nonaka, SG Van Lanen

文献索引：Chi, Xiuling; Pahari, Pallab; Nonaka, Koichi; Van Lanen, Steven G. Journal of the American Chemical Society, 2011 , vol. 133, # 36 p. 14452 - 14459

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被引用次数: 20

摘要

Several peptidyl nucleoside antibiotics that inhibit bacterial translocase I involved in peptidoglycan cell wall biosynthesis contain an aminoribosyl moiety, an unusual sugar appendage in natural products. We present here the delineation of the biosynthetic pathway for this moiety upon in vitro characterization of four enzymes (LipM-P) that are functionally assigned as (i) LipO, an l-methionine: uridine-5′-aldehyde aminotransferase;(ii) LipP, a 5 ...