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Lipidic peptides, I. Synthesis, resolution and structural elucidation of lipidic amino acids and their homo??and hetero??oligomers

…, M Charalambous, M Christodoulou…

文献索引:Gibbons, William A.; Hughes, Richard A.; Charalambous, Mario; Christodoulou, Marika; Szeto, Alice; et al. Liebigs Annalen der Chemie, 1990 , # 12 p. 1175 - 1183

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被引用次数: 131

摘要

Abstract The α-amino acids with long alkyl side chains, the so-called lipidic amino acids 1a– e, and their homo-oligomers, the lipidic peptides 1p–aj, represent a class of compounds which combine the structural properties of peptides and proteins with the characteristics of lipids and membranes. The amino acids were synthesised from the appropriate alkyl bromide and diethyl acetamidomalonate. Resolution was made chemically, by forming ...