Identification of a more potent analogue of the naturally occurring alkaloid huperzine A. Predictive molecular modeling of its interaction with AChE

…, G Campiani, LQ Sun, S Wang, A Saxena…

文献索引：Kozikowski, Alan P.; Campiani, Giuseppe; Sun, Li-Qiang; Wang, Shaomeng; Saxena, Ashima; Doctor, Bhupendra P. Journal of the American Chemical Society, 1996 , vol. 118, # 46 p. 11357 - 11362

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被引用次数: 92

摘要

Huperzine A (HA), a potent reversible inhibitor of acetylcholinesterase (AChE), is an important psychotherapeutic agent for improving cognitive function in Alzheimer's patients through the enhancement of central cholinergic tone. This molecule takes on added value in that it has recently been shown to exhibit neuroprotective properties (glutamate toxicity blocking activity) in vitro. Based upon our cumulative SAR information and to some extent ...