Identification of a more potent analogue of the naturally occurring alkaloid huperzine A. Predictive molecular modeling of its interaction with AChE

…, G Campiani, LQ Sun, S Wang, A Saxena…

Index: Kozikowski, Alan P.; Campiani, Giuseppe; Sun, Li-Qiang; Wang, Shaomeng; Saxena, Ashima; Doctor, Bhupendra P. Journal of the American Chemical Society, 1996 , vol. 118, # 46 p. 11357 - 11362

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Citation Number: 92

Abstract

Huperzine A (HA), a potent reversible inhibitor of acetylcholinesterase (AChE), is an important psychotherapeutic agent for improving cognitive function in Alzheimer's patients through the enhancement of central cholinergic tone. This molecule takes on added value in that it has recently been shown to exhibit neuroprotective properties (glutamate toxicity blocking activity) in vitro. Based upon our cumulative SAR information and to some extent ...