Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza

SJF Macdonald, R Cameron, DA Demaine…

文献索引：Rosa, Joaquin Campos; Galanakis, Dimitrios; Piergentili, Alessandro; Bhandari, Kalpana; Ganellin, C. Robin; Dunn, Philip M.; Jenkinson, Donald H. Journal of Medicinal Chemistry, 2000 , vol. 43, # 3 p. 420 - 431

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被引用次数: 96

摘要

... Journal of Medicinal Chemistry. ... figure Scheme 1. Synthesis of 8 and 13 a. a Reagents and conditions: (a) O 2 NC 6 H 4 OCOCl, DMAP, pyridine; (b) 6, 57% or 11, 49%; (c) anisole, CF 3 CO 2 H, CH 2 Cl 2 ; (d) Et 3 N, H 2 O, MeOH then preparative HPLC 52% for 8, 50% for 13 ...