Tetrahedron Letters

An expedient synthesis of 3-substituted indoles via reductive alkylation with ketones

JR Rizzo, CA Alt, TY Zhang

文献索引：Rizzo, John R.; Alt, Charles A.; Zhang, Tony Y. Tetrahedron Letters, 2008 , vol. 49, # 48 p. 6749 - 6751

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被引用次数: 16

摘要

3-Alkylindoles were prepared in one step from indoles and ketones via a convenient reductive alkylation procedure using triethylsilane and trichloroacetic acid. Under this particular condition, unsubstituted indoles could be tolerated to afford good yields of 3-sec- alkylation products.