Tetrahedron letters

Efficient one-pot formation of 4-N-substituted 2, 4-dihydro-3H-1, 2, 4-triazolin-3-ones from primary amines using N′-(ethoxymethylene) hydrazinecarboxylic acid …

…, C Wang, X Huang, D Xiao, A Palani, R Aslanian…

文献索引：Shao, Ning; Wang, Cheng; Huang, Xianhai; Xiao, Dong; Palani, Anandan; Aslanian, Robert; Shih, Neng-Yang Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6743 - 6746

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被引用次数: 7

摘要

(E)-N′-(Ethoxymethylene) hydrazinecarboxylic acid methyl ester was synthesized in one step in good yield. This reagent was successfully applied to the one-pot synthesis of 4- substituted 2, 4-dihydro-3H-1, 2, 4-triazolin-3-ones from readily available primary alkyl and aryl amines. This reaction process is relatively mild and easy to carry out. It is especially useful for the formation of sterically hindered triazolinones, which are otherwise difficult to ...