Organic letters

Copper-Catalyzed Domino Synthesis of Quinazolinones via Ullmann-Type Coupling and Aerobic Oxidative C− H Amidation

W Xu, Y Jin, H Liu, Y Jiang, H Fu

文献索引：Xu, Wei; Jin, Yibao; Liu, Hongxia; Jiang, Yuyang; Fu, And Hua Organic Letters, 2011 , vol. 13, # 6 p. 1274 - 1277

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被引用次数: 135

摘要

An efficient copper-catalyzed approach to quinazolinone derivatives has been developed, and the protocol uses cheap and readily available substituted 2-halobenzamides and (aryl) methanamines as the starting materials as well as economical and environmentally friendly air as the oxidant. This can be the first example of constructing N-heterocycles via sequential Ullmann-type coupling under air and aerobic oxidative C− H amidation.