Stereoselective reduction of alkyl 3-oxobutanoate by carbonyl reductase from Candidamagnoliae

Y Yasohara, N Kizaki, J Hasegawa, M Wada…

文献索引：Yasohara, Yoshihiko; Kizaki, Noriyuki; Hasegawa, Junzo; Wada, Masaru; Kataoka, Michihiko; Shimizu, Sakayu Tetrahedron Asymmetry, 2001 , vol. 12, # 12 p. 1713 - 1718

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被引用次数: 83

摘要

The enantioselective reduction of alkyl 3-oxobutanoates by carbonyl reductase (S1) from Candidamagnoliae was investigated. S1 reduced alkyl 4-halo-3-oxobutanoates to the corresponding enantiomerically pure (S)-3-hydroxy esters. Escherichiacoli HB101 transformant co-overproducing the S1 and glucose dehydrogenase from Bacillusmegaterium, produced optically pure alkyl 4-substituted-3-hydroxybutanoates in a ...