Tetrahedron

Synthesis of an indole containing KDR kinase inhibitor by tandem Sonogashira coupling-5-endo-dig-cyclization as a key step

SS Palimkar, VS More, PH Kumar, KV Srinivasan

文献索引：Palimkar, Sanjay S.; More, Vijaykumar S.; Kumar, P. Harish; Srinivasan, Kumar V. Tetrahedron, 2007 , vol. 63, # 51 p. 12786 - 12790

全文：HTML全文

被引用次数: 16

摘要

Various methods for the synthesis of compound 1 have been reported (Fig. 1) in the literature such as Suzuki coupling, reductive condensation of nitroketone, Fischer indole synthesis, palladium-catalyzed cyclization of imine, and cyclization of nitrostyrene. 2a Very recently the synthesis of compound 1 using palladium-catalyzed tandem C–N/Suzuki coupling reaction has been reported by Lautens et al. 4 Palladium-catalyzed annulation of o-halo anilines with ...