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Tetrahedron

Synthesis of pyrido [2′, 1′: 2, 3] imidazo [4, 5-b] quinoline and pyrido [1′, 2′: 1, 2] imidazo [4, 5-b] quinoline and their benzo and aza analogs via tandem catalysis

KTJ Loones, BUW Maes, RA Dommisse

文献索引:Loones, Kristof T.J.; Maes, Bert U.W.; Dommisse, Roger A. Tetrahedron, 2007 , vol. 63, # 36 p. 8954 - 8961

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被引用次数: 26

摘要

In this paper we report regioselective tandem metal-catalyzed aminations on dihaloquinolines (2-chloro-3-iodoquinoline and 2, 3-dibromoquinoline) with amino (benzo)(di) azines. Eight new heterocyclic scaffolds of the dipyridoimidazole type could be synthesized. By controlling the reaction temperature selective C-2 intermolecular Pd- catalyzed amination on 2, 3-dibromoquinoline with amino (benzo)(di) azines can be ...