4-(1H-Indazol-5-yl)-6-phenylpyrimidin-2 (1H)-one analogs as potent CDC7 inhibitors

…, C Bellamacina, TG Gesner, A Yabannavar…

文献索引：Shafer, Cynthia M.; Lindvall, Mika; Bellamacina, Cornelia; Gesner, Thomas G.; Yabannavar, Asha; Jia, Weiping; Lin, Song; Walter, Annette Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 16 p. 4482 - 4485

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被引用次数: 29

摘要

A series of 4-(4-hydroxyphenyl)-6-phenylpyrimidin-2 (1H)-ones were identified by HTS as inhibitors of CDC7. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus on removing potential metabolic liabilities and improving cellular potency.