Synthesis

Functionalized Carbodiimide Mediated Synthesis of 2, 3-Disubstituted Quinazolin-4 (3H)-ones via the Tandem Strategy of C-Nucleophilic Addition and Intramolecular …

H Nakano, N Kutsumura, T Saito

文献索引：Nakano, Hayato; Kutsumura, Noriki; Saito, Takao Synthesis (Germany), 2012 , vol. 44, # 20 p. 3179 - 3184

被引用次数: 5

摘要

Abstract A facile synthesis of quinazolin-4 (3 H)-ones possessing carbon substituents at positions 2 and 3 has been developed. Key to the synthesis is a tandem strategy involving introduction of a 2-substituent and construction of the quinazolinone framework via C- nucleophilic addition to the carbodiimide cumulenic carbon followed by intramolecular nucleophilic substitution by the newly formed NH moiety at the proximal ester group.

~68%

查看详情

查看详情

查看详情

~96%

查看详情

~33%

查看详情

查看详情

查看详情

查看详情

查看详情

~89%

查看详情

查看详情

查看详情

~92%

查看详情

~81%

查看详情

~49%

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

Synthesis and structure–activity relationship of 3-phenyl-3H...

[Storelli, Stefania; Verdijk, Pauline; Verzijl, Dennis; Timmerman, Henk; Van De Stolpe, Andrea C.; Tensen, Cornelis P.; Smit, Martine J.; De Esch, Iwan J. P.; Leurs, Rob Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2910 - 2913]

Synthesis of 3H??Quinazolin??4??ones and 4H??3, 1??Benzoxazi...

[Kumar, R. Arun; Maheswari, C. Uma; Ghantasala, Satheesh; Jyothi; Reddy, K. Rajender Advanced Synthesis and Catalysis, 2011 , vol. 353, # 2-3 p. 401 - 410]