Studies on the synthesis and anti-osteoporosis of estrogen-GHRPS linkers

C Wang, W Cui, M Zhao, J Yang, S Peng

文献索引：Wang, Chao; Cui, Weina; Zhao, Ming; Yang, Jian; Peng, Shiqi Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 1 p. 143 - 146

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被引用次数: 11

摘要

The linkers of estrogen-GHRPs were prepared by the combination of estradiol, estrone, TyrGlyGlyPheLeuOH, and TyrGlyGlyPheLeuOH. Their anti-osteoporosis effect was evaluated by analyzing the data, for instance the weight of the body, femur, femur ash, the content of calcium and phosphor in the femur, the content of calcium and ALP activity in the serum, obtained from the corresponding bioassay in vivo. The results indicated that the ...