Chemistry of Natural Compounds

Synthesis of enkephalins by the method of polymeric activated esters based on 4-hydroxy-3-nitrobenzophenone

EI Grigor'ev, SV Chernova

文献索引：Grigor'ev, E. I.; Chernova, S. V. Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 468 - 474

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摘要

Abstract Leucine-and methionine-enkephalins have been synthesized by the successive growth of the peptide chain from the C-end by the method of polymeric activated esters based on 4-hydroxy-3-nitrobenzophenone with yields of 90 and 70%, respectively, calculated on the initial C-terminal amino acid. Polystyrene with 2% of divinylbenzene was used as the polymeric matrix. Using the synthesis of methionine-enkephalin as an ...